Open Seminars of the Research Group on

 

Stochasticity and Control in the Dynamics and Diversity of Immune Repertories: an Example of Multi-Cellular Co-Operation

 

Tuesday, June 6, 2017, 12:00

at the Israel Institute for Advanced Studies, Room 128

 

 

Building Models for Understanding and Engineering Gene Expression Dynamics

 

Tamir Tuller (TAU)

 

Gene expression is a fundamental process that occurs in all cells and is related to all biomedical phenomena. Gene expression is encoded in different parts of the genome in a non-modular manner and based on organism specific codes. Thus, today we understand only a small fraction of the gene expression codes, and most of the gene expression models are very partial and can provide very limited predictions. In our research we aimed at developing generic/universal approaches for understanding, modeling and engineering the way gene expression is encoded in the genetic material. In this talk I will review our multidisciplinary strategy and concepts, and some recent key results. Among others, I will describe whole cell biophysical simulations of translation, and unsupervised information theoretic approaches for gene expression modeling. I will demonstrate how these tools can help us understand fundamental phenomena in molecular evolution and functional genomics, and will demonstrate some biotechnological applications related to our models.
 

 

 

Related Research Questions

 

  1. How silent mutations in the transcript constrain and effect its evolution?
  2. Is it possible to map sub-sequences of the genetic material to complex biophysical aspects of gene expression? 
  3. Is it possible to automatically decipher and engineer gene expression aspects? 

 

Suggested Reading

 

http://www.cs.tau.ac.il/~tamirtul/Selected_publications/NAR-2017.pdf
http://www.cs.tau.ac.il/~tamirtul/Selected_publications/Interface2016.pdf
http://www.cs.tau.ac.il/~tamirtul/Selected_publications/RNA_BIOL_2015.pdf
http://www.cs.tau.ac.il/~tamirtul/Selected_publications/NAR2015.pdf
http://www.cs.tau.ac.il/~tamirtul/Selected_publications/Bioinformatics2014.pdf

 

 

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