Stochasticity and Control in the Dynamics and Diversity of Immune Repertoires: an Example of Multi-Cellular Co-Operation

 
March 26- June 30, 2017
 
Organizers: Uri Hershberg and Gur Yaari
 
We propose to study the general problems of functionality and robustness in complex biological systems, through a focus on the adaptive immune response as a model system. The adaptive immune response is a complex system, which comprises many interacting cells that are subject to various sources of stochasticity. We will address fundamental questions in the field such as how B and T cell repertoires collectively go through a process of stochastic diversity generation and clonal selection, and consistently yield functional controlled immune responses in a noisy environment. This understanding will be important in developing control strategies to modulate the immune response (e.g., with vaccinations or immune therapies) since, while predictable in the aggregate, human immune responses can display marked variability. For example, a small fraction of individuals do not raise antibodies following influenza vaccination, and efficacy rates for vaccination in older individuals are generally under 30%. Infections with West Nile virus are usually asymptomatic, but some patients experience severe neurological disease and even death. The potential role of stochasticity at different spatial and temporal scales in driving these diverse yet robus responses will be a main focus of our research group.
 
 
 
Participating Scholars:
 
Sol Efroni, Bar-Ilan University
Nir Friedman, Weizmann Institute of Science
Ronald B. Gartenhaus, University of Maryland
Andrew Collins, University of New South Wales
Uri Hershberg (Organizer), Drexel Univeristy
Michal Or-Guil, Humboldt University
Gur Yaari (Organizer), Bar-Ilan University
 
Long-Term Visiting Scholars:
 
Phil Hodgkin, Walter and Eliza Hall Institute of Medical Health
Michael Levitt, Stanford University 
 

Seminars:

 

DateTime and SpeakerTitleType
Tuesday 28.3.2017

12:00  
Avigdor Eldar

Eco-evolutionary dynamics of microbial communication - me, us and themOpen seminar

14:00 
Nadav Kashtan

Bacterial decision making on unsaturated surfaces
Tuesday 4.4.201712:00
Yoni Savir
Yeast response to multiple carbon sources: a case study of combinatorial signal integrationOpen seminar
14:00 
Naama Barkai

How ‘noise’ can help microorganisms adapt to fluctuating environment?

Wednesay 19.4.201712:00
Ruti Hershberg
From boom to bust - the dynamics of bacterial adaptation under prolonged resource exhaustion.Open seminar
14:00 
Omry Koren
We are not alone: a meeting with your gut microbiome
Tuesday 25.4.201712:00
Benny Chain
The T cell receptor repertoire in lung cancerOpen seminar
14:00 
Using technology to negotiate genotype-phenotype interface in health and disease
Wednesday 3.5.201712:00
Michael Assaf
Aspects of stochastic population dynamics in gene expression and cellular decision makingOpen seminar
14:00 
Uri Nevo
Ecology resolves the complexity of immune self-tolerance
Tuesday 9.5.201712:00
Erez Braun
Hydra regeneration: A window on morphogenesisOpen seminar
14:00 
Leila Perie
Following T cell differentiation at the single cell level using cellular barcoding
Tuesday 16.5.201712:00
Mickey Kosloff
Deciphering the structural design principles for interaction specificity among signaling proteinsOpen seminar
14:00 
Eran Meshorer
Epigenetics and expression heterogeneity in mouse embryonic stem cells
Tuesday 23.5.201712:00
Sarel Fleishman
Learning from antibodies how to design new protein functionsOpen seminar
Monday 29.5.201712:00
Tomer Kalisky
Cellular heterogeneity in kidney tissues and tumorsOpen seminar
14:00 
Naama Brenner
Exploratory adaptation in gene regulatory networks
Tuesday 6.6.201712:00
Tamir Tuler
Building Models for Understanding and Engineering Gene Expression DynamicsOpen seminar
14:00 
Adi Stern
Viral evolution: living on the edge
Tuesday 13.6.201712:00
Tal Shay
Challenges in extracting splicing preference from single RNA-sequencing dataOpen seminar
14:00 
Martin Flajnik
The origins of cellular selection in adaptive immunity